By Stephen M. Schwartz, Robert P. Mecham

ISBN-10: 0126323100

ISBN-13: 9780126323108

Within the final numerous years, the improvement of reagents that realize tender muscle-specific proteins has enabled researchers to spot delicate muscle cells (SMC) in tissue present process either differentiation and service. those advancements have resulted in elevated study on SMC. the newest quantity within the Biology of the Extracellular Matrix sequence takes a present and all-encompassing examine this turning out to be quarter of study. dedicated solely to the topic of SMC, the ebook covers a variety of topics-from SMC structure and contractility to differentiation and gene expression in improvement. It additionally examines the proliferation and replication of SMC and its position in pharmacology and vascular illness. A needs to for telephone, developmental, and molecular biologists, this e-book will also attract cardiologists, pathologists, and biomedical researchers drawn to gentle muscle cells. Key good points * offers a molecular, genetic, and developmental viewpoint of the vas tender muscle telephone * evaluation sections spotlight key issues of chapters, together with the medical relevance of the study and expectancies for destiny research * Appeals to either the elemental biologist and to the biomedical researcher of vascular sickness

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Additional info for The Vascular Smooth Muscle Cell: Molecular and Biological Responses to the Extracellular Matrix (Biology of Extracellular Matrix)

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Alexander, R. , and Gimbrone, M. , Jr. (1984). Myosin in cultured vascular smooth muscle cells: Immunofluorescence and immunochemical studies of alterations in antigenic expression. J. Cell Biol. 99, 1582-1589. Lee, K. T , Lee, K. , Lee, S. , and O'Neal, R. M. (1970). Poorly differentiated subendothelial cells in swine aortas. Exp. Mol. Pathol. 13, 118-129. , Benditt, E. , and Schwartz, S. M. (1988). Expression and developmental control of platelet-derived growth factor A-chain and B-chain/Sis genes in r a t aortic smooth muscle cells.

The Id gene is activated by serum but is not required for de-differentiation in rat vascular smooth muscle cells. Biochem. J. 277, 2 8 5 - 2 8 8 . Kirby, M. , and Bockman, D. A. (1984). Neural crest and normal development: A new perspective. A/2a^. Rec. 209, 1-6. Lassar, A. , Thayer, M. , Overell, R. , and Weintraub, H. (1989). Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoDl. Cell 58, 6 5 9 - 6 6 7 . Majesky, M. , Benditt, E. , and Schwartz, S. M. (1988).

Media formation in the rat embryo. (A) At 11 days of gestation, an uneven distribution of actin expression (arrows) is observed in the dorsal aorta (312X). (B) In the 13-day-old embryo, mesenchymal condensations start to develop (arrows) and actin expression is spreading around the dorsal aorta (195X). (C) A medial layer is now present around the complete dorsal aorta. The initial side of actin expression (arrows) can still be recognized in the 14day-old embryo (175X). 22 23 SMOOTH MUSCLE CELL DIFFERENTIATION %% 2A FIG.

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The Vascular Smooth Muscle Cell: Molecular and Biological Responses to the Extracellular Matrix (Biology of Extracellular Matrix) by Stephen M. Schwartz, Robert P. Mecham

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